The contestant is shown four prizes and a target price. They must select the two prizes whose prices total the target price to win all four prizes. If the total is incorrect, the contestant is given one more opportunity to pick the correct two, now knowing the prices of the two prizes they selected first. If the total still does not match the target price, he/she lost the game. If the total is correct on either chance, the contestant wins all four prizes. Unlike Pick-A-Pair, if the player uses their second chance, they don't have to keep one of the choices from their first selection.
- When the game debuted on June 23, 1978 (#2875D, aired out of order on June 2, 1978), the game board was a square board, with an extra part behind it. Originally, the game board was pink with white trim, with the dollar signs and price slips white, the board covering the names of the prizes white with pink dots for each prize, the extra part in white, and the name of the game blue. Also there were two dollar signs at the top area. The colors were changed on March 11, 1983 (#4835D), with the board yellow, purple for the dollar signs and the price slips, orange for the board covering the prizes, and the trim of the board purple and yellow, with the name of the game in purple, and the extra part in a purple & orange color. And the two dollar signs at the top were replaced with one big dollar sign.
- On April 16, 1997 (#0343K), the game board was changed to its current appearance. The font for the target price, prices/prizes was changed on October 22, 2009 (#4874K).
- On December 3, 2008 (#4533K, aired out of order on November 26), the game was taken out of the rotation, but returned on October 22, 2009 (#4874K).
- Starting on December 9, 2013 (#6521K, aired out of order on December 16) the game board was moved behind the curtain next to the first prize when revealing the four prizes, and then after the prize descriptions ended, the prop comes out to its usual position; this new staging is similar to Race Game a few days earlier.
- So far, the show's logo on the game setup is still the one used from Bob Barker's era. There is still no straight answer on when the game is going to have the show's logo under Drew Carey's tenure.
- Take Two was only played once on primetime TV and it was the only playing to receive a win.
- Take Two has never been the first pricing game to be played on the show.
- Before the game starts, 2 of the 4 prizes are chosen at random. They study the actual retail prices in secret and add them together to make it today's target price.
- The most number of times this game was played in any season was 42.
- Take Two bears similarity with Race Game but without time limit.